I have to be honest it took me a while to figure out how they come to 21 games per team but I have it now. The solution of the Italian, Scots and SA teams playing an additional derby game seems simple enough.
I have develped a fear of conferences over these last two years but I would compare this format favorably to the S15. And in S15 the format wasn't broken yet and this one has a lot more going for it;
1) every team plays every other at least once whereas in S15 you'd miss one team from each of the other conferences,
2) there are 2 conferences as opposed to 3,
3) they are comprised of teams from each nation rather than each nation on its own to compensate for probable disparities in relative strengths and then lastly
4) played in the same time zone (near enough) which IMO > same hemisphere
21 Matches is rough though when you consider we are used to 15 per season for SR. I suppose the Cheetahs will be forced t sacrifice their CC campaign although they are going at it full tilt ATM. Maybe hoping to come into the Pro14 match fit seeing as there is a decent amount of rest on the cards soon enough and the tournament is played in patches. I wouldn't know.
I wouldn't expect either SA team to be doing terribly well off the bat though; player rotations, no real break between SR and Pro14 and culture (rugby-wise)- and climate shock are probably to translate into early season losses I'd expect. I'm still excited to see how it plays out and whether there is a real win-win opportunity to make a move en-masse.