Earlier this season Nowell got comfortably caught having intercepted. He is a good enough player that he managed to link up with others but his lack of gas is clearly a problem. Rush defences rely on a fast winger to cover in the eventuality that teams manage to get round the back. Nowell perhaps was also a bit too far in, making the problem worse.
Roko has been great this season in a terrible team. Yarde has also played well, whilst May was electric in the World Cup warm ups.
I'd also still like to experiment with Wade. He scores tries other players can't. His defence is probably not good enough but his size and astonishing acceleration of the mark allows him to create things that others can't. It may be romantic though to think that he can cut it...
What Nowell does do is always beat the first man which makes his kick return game really valuable. Roko and Wade are also good at this though...