Post WC I'd be fine at looking at our 3rd choice 10 who can get a crack in autumn internationals etc and generally move towards rotating the England squad more over a regular period but I don't think replacing Ford or Farrell is particularly important. Think at what point Sexton became considered one of the best 10's in the world, it was late 20's at best. I think a position where we need to clear out the incumbents and really get new blood asap is 9. Ford and Farrell have room to still develop, Care and Youngs don't, short of something drastically changing for Youngs.
In order of priority, these are positions I think we need to look at getting new blood in or giving some slightly older players their chance:
9
12
2, 15
6, 7, 8
1, 3
Rest aren't an issue and a player who is good enough to force their way into the team is more a bonus than something we really need to look at. I'd also say they don't all have to be young players, just form players. Wilson has highlighted that very well. Many of those positions we have good first choice players but will need to look at developing the 2nd string. England look to have some serious talent coming through in all those positions though, it's just a case of the clubs properly helping their development and England coaches making sensible selections. Saracens really are in their own league for developing players, although Chiefs seem to have become a good breeding ground for them too. Many other prem clubs need to step up and improve their academies rather than buying in players.