For the team v Italy i think a few changes would be good, but we need to avoid wholesale changes.
It's a great opportunity for George to start, and i think wort giving Watson a shot at fullback.
We need more quick ball. I personally would retain Youngs as i think the pack and the breakdown were a bigger issue than scrum half most of the time v Wales. The back row needs tweaking for this. After Lawes/Launchberry's performances i don't see EJ moving Itoje up to the second row so maybe starting Haskell will be the thing to do. Possibly starting Teo to give us an additional hard yards ball carrier- but would be at expense of JJ or Ford (less likely).
Youngs usually is better with game-management than Care so i think would be a better starter if we are worried about the Italian pack trying to turn the contest into an arm-wrestle. As the game loosens up Care can come on to help up the pace. If we can up the pace from the first minute then start Care, but with the change in balance of the pack from last yr i don't feel confident we can avoid a slower game/armwrestle initially.