I see no point in risking Mako and Watson against the Italians by starting then, give them each a good 30 mins off the bench to get back into the mix of things so that they can start against Scotland.
I've put May in as I think he should be on that wing to stay. Watson should be replacing Brown at FB and Daly's not a winger.
I've suggested JJ coming off as we already know we he can do, he doesn't need a full game vs the Italians to show it. I think getting Daly a good 1/2 hour at 13 would overall be much more beneficial to the team and to our depth.
I too prefer Maro at lock but it seems that this Six Nations he's going to stay at 6, and I think vs the Italians is a real opportunity for him to gain some confidence there.
On Slade, I'd like to see him in but I don't know where. In my mind he's a 12, and I'm more interested in seeing what Te'o can do with a start than what Slade can. Going for an all new look midfield by putting him at 13 also seems too risky. Maybe the 22 shirt, but I can't see it happening.