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South Africa duo Chiliboy Ralepelle and Bjorn Basson have been suspended and sent home after failing drugs tests.
Hooker Ralepelle and winger Basson tested positive for a banned stimulant following the Springboks' 23-21 win over Ireland in Dublin on 6 November.
Both played in Saturday's 29-25 victory against Wales, Ralepelle coming on as a late substitute while Basson started.
The South African Rugby Union was told of the positive tests late on Sunday and it has suspended both players.
Six Nations Rugby Ltd, who administers the November internationals, informed the South Africans of their findings and as a result the pair have been sent home.
Basson was due to fly back on Monday in any event as he injured his ankle in the victory over Wales and had been ruled out of the rest of the tour.
The 23-year-old winger, won the third of his four caps in the 23-21 win against Ireland and is the record holder for the most tries in a Currie Cup campaign.
He started the game against Ireland, while Ralepelle was an unused substitute.
The 24-year-old hooker has made 17 international appearances and he was the first black player to captain the national side when he led them out against a World XV in Leicester.
Both players tested positive for methylhexaneamine, a "non-specified stimulant" on the prohibited substances list of the World Anti-Doping Agency (Wada).
Methylhexaneamine is scheduled to be reclassified as a "specified stimulant" from 1 January 2011.
The players have the right to request that their 'B' sample be tested.
http://news.bbc.co.uk/sport1/hi/rugby_union/9190833.stm
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