That is a lot of likely squad members ruled out. Reckon we see something like:
Hookers: George, Walker
Props: Genge, Obano, Sinckler, Stuart
Locks: Launchbury, Clarke, Ewels (is he even fit yet? Lock is very hard. Itoje, Isiekwe, Hill, Ribbans, Chessum and Martin all unavailable)
Back Rowers: Willis, Pearson, Rogerson, T. Hill (probably doing a lot of filling in at lock), Mercer, Dombrandt, Simmonds
Scrum Halves: Care, Spencer, Randall
Fly Halves: Smith, Bailey
Centres: S. Atkinson, Slade, Lawrence, Marchant
Back Three: Hassell-Collins, May, Loader, Murley, Arundell