I get the point about the long time without game time etc but to be honest I'm quite worried about fullback & prop if one of Keenan/Porter/Furlong get injured. If Keenan gets injured I'd be concerned about anyone who replaces him. Lowry is the in form choice but has 0 international experience, Larmour I'm really not confident about. Conway would fill it I guess? But then that leaves the right wing position open for Baloucoune who, again, has next to no international experience.
I wouldn't be too keen on throwing Bealham/O'Toole in the deep end in a crucial RWC game either. I get a home game vs Italy isn't going to be career defining but it's a big enough occasion for those who have little to no experience.
Second Row/Backrow/SH/10/Centre/LW seem to be well covered. 10 on the basis that Carbury did well last week but the 3rd choice is obv a big drop off which has been discussed in length on here.