Given the forwards to backs ratio another 6-2 split seems likely.
I'd guess at
1. Genge 2. George 3. Sinckler
4. Kris 5. Itoje
6. Ludlam 8. Curry 7. Underhill
9. Youngs 10. Ford
12. Farrell 13. Tuilagi
11. Daly 15. Furbank 14. May
16. LCD 17. Marler 18. Stuart
19. Launchbury 20. Lawes 21. Earl
22. Heinz 23. Slade
Although he does seem to hate the idea of dropping Joseph from the 23 so possible we'll see him in instead of one of the forwards, probably Launchbury. Or he could drop Ford and start Slade. Or he could swap Marler/Genge and Youngs/Heinz. I don't know and it is Eddie so who knows really.
Either way, I think we have just about enough to beat that team away, they're roughly equal in the tight 5 imo and I'd give us the edge over that backrow (unless we're unlucky and Earl starts at 8 with Curry at 6, in which case I'd very much back the English backrow over ours.
No one is particularly delighted about their 9s and I'd give Sexton the edge at 10, we should have physical enough centres to limit Manu's impact even if he's fully fit, and our back three is made up of good players in form. That's an optimistic reading of things it's mot going to be easy, but bottom line I think we can win, although I wouldn't be surprised if England beat us, and quite comfortably at that.