Howells already made a wild experiment by starting Popa against Canada.
Despite their very poor results this autumn, Uruguay deserves respect. I hope Howells will keep an experienced backbone of the team but include all the youngsters who didn't play at all so far in November. Popa, Gordas, Chirica, Antonescu could be starters. Pristavita, Bardasu, Muresan, Bratu, Melniciuc, Plai, Onutu and Simionescu should either start or at least be on the bench.
I'd keep Fonovai, Umaga and Gorcioaia in the lineup since they need more matches to become integrated with the national team.