I played through the first level on Uncharted 2 (the train) and will confess to being thoroughly underwhelmed. Visually it's nice (not stunning, just nice) and the animated cut scenes are excellent, but as a game play experience I found it clunky and unforgiving, a bit like going back to the original Tomb Raider after playing the silky smooth remake.
In the controller front - DualShocks are chuffing horrible things. I bought myself a MadCatz Dualforce 3 along with the PS3, just because it's a good chunky pad with sticks that don't move on their own free will. Plus it also has removable AA batteries instead of a built in rechargeable battery, so it's not as much a pain in the arse when the power runs out.
Still, the only exclusive PS3 ***les I've enjoyed are Little Big Planet and Motorstorm. All my other good games for it are available for every other console anyway.