Handicaps currently with the bookies

Clermont (-6) V Toulon (+6)

Munster (-6) V Toulouse (+6)

Saracens (-14) V Glasgow (+14)

Leinster (-4) V Wasps (+4)

You'd have to respect Saracens record in this competition but (-14) seems a bit generous. Expect it'll be tighter than that. I'd take all four home teams to win outright though.